If you are travelling to a destination where malaria is a risk, it is important to understand when you should start malaria tablets. Timing matters because these medicines need to be in your system before you are exposed, and you usually need to continue taking them after you return home.
At Brixton Travel Clinic, we help travellers plan their protection properly, whether you are leaving in a few months or flying out at short notice. As a trusted travel clinic in London, our goal is to make travel health advice simple, practical, and easy to follow.
If you want personalised advice for your trip, contact us and we can recommend the most suitable option based on your destination and medical history.
Why Do You Need To Start Malaria Tablets At The Right Time?
Malaria tablets work by helping prevent malaria infection if you are bitten by an infected mosquito. Starting on the correct day gives the medicine time to reach effective levels in the body.
Starting too late may reduce protection, while starting too early without guidance can lead to unnecessary side effects or wasted medication. This is why we always recommend planning in advance where possible.
To get your timeline confirmed before you travel, book now with Brixton Travel Clinic for a quick, professional consultation.
Simple Timeline: When To Start Malaria Tablets
The right start date depends on which type of malaria tablets you are prescribed. Your travel itinerary and length of stay can also influence the best option.
Here is a simple overview of common timings:
- Some malaria tablets start 1 to 2 days before travel
- Others need to start 1 week before travel
- Some require starting 3 weeks before travel

Even if you are travelling soon, it is often still possible to protect yourself with the right medication choice.
FAQ: When Should I Start Malarone?
Malarone is one of the most commonly used malaria tablets for travellers because it has a shorter lead-in time and is often well tolerated.
A simple timeline for Malarone is:
- Start 1 to 2 days before entering the malaria risk area
- Take it every day while you are in the risk area
- Continue for 7 days after leaving the risk area
This makes Malarone a popular option for last-minute trips, short travel itineraries, and people who want a shorter course after returning home.
If you are unsure whether Malarone is right for your trip, get in touch with us for tailored advice.
FAQ: When Should I Start Doxycycline For Malaria Prevention?
Doxycycline can also be used as malaria prevention, particularly for longer trips and certain destinations. It requires taking it for longer after travel, so it is important to factor that into your planning.
A simple timeline for doxycycline is:
- Start 1 to 2 days before entering the malaria risk area
- Take it every day while you are away
- Continue for 4 weeks after leaving the malaria risk area
Doxycycline can make some people more sensitive to sunlight, so it may not be ideal for everyone depending on the destination and the type of holiday you are taking.
If you want help choosing the best option, book an appointment with Brixton Travel Clinic.
FAQ: When Should I Start Mefloquine?
Mefloquine is taken weekly rather than daily, but it needs to be started well in advance. This is because some people experience side effects and may need to switch to another option.
A simple timeline for mefloquine is:
- Start at least 2 to 3 weeks before entering the malaria risk area
- Take it weekly while travelling
- Continue for 4 weeks after leaving the risk area
Mefloquine is not suitable for everyone, particularly people with certain mental health conditions. This is why a travel consultation is essential.
To confirm suitability, contact us and our travel health team will guide you.
FAQ: What If I Am Travelling Very Soon?
If your trip is coming up quickly, you may still be able to start malaria tablets in time. The key is choosing the right medication based on how soon you depart and your individual health profile.
For last-minute travel, we often recommend options that:
- Can be started 1 to 2 days before travel
- Are easy to take consistently
- Match your destination-specific malaria risk
If you are travelling within the next few days, book today and we will help you organise protection and other essential vaccines as quickly as possible.
FAQ: Do I Need Malaria Tablets For Every Country?
No, malaria risk varies widely by country and even by region within the same country. Some popular destinations may only carry malaria risk in rural areas or during certain seasons.
Before taking malaria tablets, it is important to consider:
- Your exact destination and travel route
- Whether you are staying in cities or rural areas
- The season and weather conditions
- Your length of stay
- Your accommodation type and activities
For accurate advice, contact us or drop in, and we will assess your itinerary properly.
FAQ: How Long Do I Need To Keep Taking Malaria Tablets After Travel?
Many travellers are surprised that malaria tablets must be continued after they return home. This is because malaria parasites can remain in the body after exposure, and the medication helps prevent infection from developing.
A quick summary:
- Malarone: continue for 7 days after leaving the risk area
- Doxycycline: continue for 4 weeks after leaving the risk area
- Mefloquine: continue for 4 weeks after leaving the risk area
If you stop too early, you may increase your risk of becoming unwell after travel.

FAQ: What If I Miss A Dose Of Malaria Tablets?
Missing a dose can happen, especially while travelling. The most important thing is to take action quickly.
General guidance includes:
- Take the missed dose as soon as you remember
- If it is nearly time for the next dose, follow the instructions given for your specific medication
- Do not double-dose unless advised
- Continue the rest of the course as normal
If you have missed doses and are unsure what to do next, contact us for advice.
FAQ: Do Malaria Tablets Fully Protect You?
Malaria tablets are highly effective when taken correctly, but no tablet offers 100% protection. This is why preventing mosquito bites remains essential alongside medication.
You should still use:
- Insect repellent with DEET or picaridin
- Long sleeves and trousers in the evenings
- Mosquito nets where appropriate
- Air conditioning or screened accommodation
Book A Malaria Consultation Before You Travel
Knowing when to start malaria tablets should not feel complicated. Once your destination and travel dates are confirmed, the right plan becomes clear, and you can travel with confidence.
At Brixton Travel Clinic, we offer trusted, straightforward travel health consultations and malaria prevention advice. If you would like to confirm which tablets you need and when to start them, book now with our team at a leading travel clinic in London.

This blog was written on behalf of Brixton Travel Clinic by Pharmacy Mentor.
